Objective Investigate the characteristics of HIV-related knowledge, attitude and behavior among general and high-risk people. Provide convincing evidences and suggestions of HIVand intervention on targeting population to promote controlling and prevention of HIV spreading.Methods Cluster stratified sampling method was used to sample the general population from 6 counties (city, district) according to the high, median, and low level of HIV epidemic in Hubei province. Sampling strata consists of county, town (community), and village (block). One town (community) was sampled in each county; three villages (blocks) were sampled in each town (community); And 30 persons were sampled in each village (block). As results, a total of 1080 persons were investigated as research subjects. A total of 120 high HIV risk persons, were sampled from Woman Penitentiaries and Drug-quitting Departments. Of them, 60 prostitutes are from two Woman Penitentiaries, and 60 IDUS are from two Drug-quitting Departments. High HIV risk persons stayed in Woman Penitentiaries and Drug-quitting Departments, at least, more than 6 months. The questionnaire, designed by Ministry of China, was used to investigate the HIV-related knowledge, attitude and behavior. Using face-to-face interviewing method, interviewer interviewed the research subjects. Before investigation, the interviewer received formal training. For the reason of human participant protection and increasing the validity of research, no other persons, except for interviewer and research subjects was there while interviewing. Furthermore, all of the private information for the research subjects kept secrets, according to written consent of this research.Results For the , all of the 1080 persons completed the questionnaire, yielding a response rate of 100.0%. A total of 1047 of them reported they ever heard of AIDS, accounted for 96.9%. Of them, 799 persons had HIVknowledge score $= 60(total score transformed to 100), accounted for 74.0%. Multivariate logistic regression model analyses indicated that persons living in the area of low level HIV spreading, living in the countryside, having lower , unmarried, and discrimination toward persons of HIV positive were more likely to have the HIV knowledge score < 60, and to be a student was more likely to have the HIV knowledge score ^60. All of the 120 high HIV risk person completed the questionnaire, generated response rate of 100.0%. A total of 111 of the 120 high HIV risk person reported they ever heard of the AIDS, accounted for 92.5%. 95 persons of them had HIV knowledge score ^60, accounted for 79.2%. Multivariate logistic regression model analyses indicated that marital status and education level was the influencing factors for the rate of HIV knowledge. Persons of unmarried, high education levels have a higher rate of HIV knowledge. Married person compared with unmarried person, OR=0.318, 95% CI=0.120-0.842 for HIV knowledge rate. While the OR=2.660, 95% CI=1.367-5.177 for person of high education level compared with low education level person. Of person-injected drugs, 41.2% of them shared syringe with their partners. Of drug users of unmarried, most of them (92.5%) had sexual experience, Female accounted for 35.0% of drug users of unmarried. Among drug users with sexual experience, 71.9% of them didn’t use condom in their latest sexual behavior. 21.7% of prostitutes didn’t use condom in their latest sexual behavior. The correct rate of knowledge of HIV transmitting was higher than that of HIV non-transmitting for bothgeneral population and high HIV risk population (general population: %2 =192.121, P<0.01; high HIV risk population: j2 =5.438, P <0.05). After controlling for theconfounding factors of gender, age, education level, martial status in logistic regression model, the OR of HIV knowledge rate was 2.305(95% CI 1.398-3.801) for high HIV risk person compared with general person. However, discrimination rate for HIV positive persons has significant difference between the groups of general population and HIV risk population.Conclusion Persons of female, of low education levels, of unmarried status, and living in the countryside have both low HIV knowledge score and HIV knowledge rate. Our results reinforced that it is necessary to implement the health education among the targeting populations, cany out the intervention measure among high HIV risk population, raise awareness of HIV, and reduce fear and panic for HIV. Our results also suggested that it is more difficult to decrease the discrimination rate of HIV than improve the HIV knowledge among population. Decreasing the discrimination rate of HIV among population is still great challenge for controlling for the HIV spreading in our country.
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